Determination of serum C-reactive protein (CRP) in healthy beagle dogs of various ages and pregnant beagle dogs.

Measurement of serum C-reactive protein concentration for discriminating between suppurative arthritis and osteoarthritis in dogs

BACKGROUND In a dog with joint pain, it is important to determine whether it has suppurative joint disease, characterized by exudation of neutrophils in the synovial fluid, or not, as this affects choice of diagnostic tests and treatments. The aim of this study was to evaluate whether measurement of serum C-reactive protein (CRP) concentration could be used to discriminate between dogs with sup...

Seasonal and circadian variations of hemodynamic and electrocardiographic parameters in telemetered beagle dogs

Quantitative evaluation of renal function in healthy Beagle puppies and mature dogs.

Daily urinary collection and assessment of glomerular filtration rate (GFR) and effective renal plasma flow were performed in ten 2-month-old Beagle puppies and ten 6-9 year-old Beagle dogs to identify age-associated differences in renal function. The most striking differences in puppies compared to mature dogs were a higher daily urinary volume (+65%), GFR (+87%), free water reabsorption (+159...

A New Model to Describe the Single-dose Pharmacokinetics of Bevacizumab and Predict Its Multiple-Dose Pharmacokinetics in Beagle Dogs

Complex pharmacokinetic (PK) properties including nonlinear elimination were encountered by some monoclonal antibodies (mAbs), and classic compartment models sometimes failed to appropriately describe those properties. In this work, a new model was built on a comprehensive analysis of the complex elimination of mAbs. This new model was firstly utilized to fit with the single-dose plasma concent...

Serum Biochemical and Hematological Parameters in Dogs with Benign Prostatic Hyperplasia (BPH)

BACKGROUND: Clinical prostatic diseases occur in 80% of dogs over 5 and 95% over 9 years of age. . It seems that benign prostatic hyperplasia) BPH) affect Scottish terriers more severely than the other breeds. OBJECTIVES: This study aimed to evaluate the changes of biochemical and hematological parameters in BPH dogs. METHODS: Blood samples were collected from 10 male dogs older than five year...